LymphedemaV1, Main, Exploration, bibRecord, 010160

The influence of various benzo-pyrones on acid and neutral protease activity levels, the cells from which they may arise and their importance in the resolution of lymphoedema

Identifieur interne : 010160 ( Main/Exploration ); précédent : 010159; suivant : 010161

The influence of various benzo-pyrones on acid and neutral protease activity levels, the cells from which they may arise and their importance in the resolution of lymphoedema

Auteurs : N. B. Piller [Australie]

Source :

Research in Experimental Medicine [ 0300-9130 ] ; 1977-06-01.

RBID : ISTEX:4762F61BBD60AEEA1F8090AA04C7ECB0DDB0D71E

Descripteurs français

KwdFr :
- Animaux, Coumarines (pharmacologie), Espace extracellulaire (enzymologie), Facteurs temps, Femelle, Lymphoedème (enzymologie), Peau (enzymologie), Peptide hydrolases (sang), Rats, Répression enzymatique ().
MESH :
- enzymologie : Espace extracellulaire, Lymphoedème, Peau.
- pharmacologie : Coumarines.
- sang : Peptide hydrolases.
- Animaux, Facteurs temps, Femelle, Rats, Répression enzymatique.

English descriptors

KwdEn :
- Animals, Coumarins (pharmacology), Enzyme Repression (drug effects), Extracellular Space (enzymology), Female, Lymphedema (enzymology), Peptide Hydrolases (blood), Rats, Skin (enzymology), Time Factors.
MESH :
- chemical , blood : Peptide Hydrolases.
- chemical , pharmacology : Coumarins.
- drug effects : Enzyme Repression.
- enzymology : Extracellular Space, Lymphedema, Skin.
- Animals, Female, Rats, Time Factors.

Abstract

Summary: The availability of digestable material to a phagocyte determines not only the rapidity and completeness of digestion but the amount of lysosomal enzyme which reaches the extracellular compartment and the circulation. The measurment of enzyme activities in thermally injured limbs has shown the benzo-pyrones to enhance acid protease activity. There is much evidence to suggest this activity originates from macrophages which enter the thermally injured regions in great numbers. In this paper the administration of benzopyrones to animals with lymphoedema is reported to enhance neutral protease activity levels. This activity is not associated with mononuclear cells but with the neutrophils. Although additional histological work must be done to confirm the presence of neutrophils in lymphoedematous tissues there is evidence to suggest the increases in neutral protease levels arise from neutrophils and that in lymphoedema it is these cells which are acted upon by the benzo-pyrones. They then cause the removal of protein by enhancing its lysis either within the cells or in the extracellular compartment.

Url:

https://api.istex.fr/document/4762F61BBD60AEEA1F8090AA04C7ECB0DDB0D71E/fulltext/pdf

DOI: 10.1007/BF01851382

Affiliations:

Le document en format XML

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<term>Lymphoedème (enzymologie)</term>
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The influence of various benzo-pyrones on acid and neutral protease activity levels, the cells from which they may arise and their importance in the resolution of lymphoedema

The influence of various benzo-pyrones on acid and neutral protease activity levels, the cells from which they may arise and their importance in the resolution of lymphoedema

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Serveur d'exploration sur le lymphœdème
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